Mechanisms of Genome Stability
Dragana Ahel
Uncovering the mechanisms that maintain genome integrity
DNA Repair Mechanisms and Human Disease
Ivan Ahel
Exploring the pathways underlying genome stability, in particular the role of the post-translational protein modification ADP-ribosylation
Caspase Functions Beyond Apoptosis
Luis Alberto Baena
The Baena-Lopez group has relocated to the Centro de Biología Molecular Severo Ochoa (CBM) in Madrid, Spain.
Organelle Biogenesis and Homeostasis
Pedro Carvalho
Investigating the role of the ER in protein degradation and organelle biogenesis.
Innate immunity and neuroinflammation
Sally Cowley
Director of the James and Lillian Martin Centre for Stem Cell Research
Molecular immunology of T cell surface receptors
Omer Dushek
Understanding how the immune system discriminates between normal and abnormal tissues, and harnessing this knowledge to develop new therapies
Genome Stability and Evolution
Fumiko Esashi
Investigating the mechanisms that drive changes in the genome during cell growth and dormancy
Molecular Mechanisms of RNA Virus Replication
Ervin Fodor
Elucidating the fundamental mechanisms underlying the replication of RNA viruses such as Influenza, Nipah, and SARS-CoV-2
Cell Biology of Signalling
Matthew Freeman
Investigating the interface between membrane proteins, the cell biology of signalling, and mechanisms of human disease
Ecology and Evolution of Microbial Communities
Kevin Foster
Ecology, evolution and the human microbiome
Macrophages, Inflammation and Drug Development
David Greaves
Using knowledge of macrophage cell biology to develop new anti-inflammatory and anti-bacterial drugs
R-Loop Biology in Health and Disease
Natalia Gromak
Studying the role of a unique type of non-canonical RNA/DNA structure in healthy cells and in neurodegenerative diseases.
Regulation of Mitotic Progression and Chromosome Segregation
Ulrike Gruneberg
Elucidating how faithful chromosome segregation during cell division is ensured, and how this goes awry in cancer
RNA Dependent DNA Damage Response and Gene Expression Regulation
Monika Gullerova
Understanding how intronic gene silencing is de-regulated in cancer cells and how synthetic tsRNA can be used therapeutically
Structure and Function of Cancer Genes
Bass Hassan
Identifying and validating functional genomic co-dependencies to improve precision of cancer treatment.
Molecular Parasitology
Matt Higgins
Unpicking host-parasite interactions in molecular detail. Matt Higgins has a joint appointment between the Biochemistry Department, the Kavli Institute and the Dunn School. His group is based in the Dorothy Crowfoot Hodgkin Building.
Germline mutation and Meiotic recombination
Anjali Hinch
Uncovering the mechanisms and impacts of meiotic recombination and de novo mutation.
Molecular Mechanisms of Bacterial Membrane Biogenesis
Georgia Isom
Using a combination of structural biology, biochemistry and bacterial genetics to study Gram-negative bacterial membrane transport systems
Macrophage Modulation During Viral Infection and Neuroinflammation
William James
William James has now retired.
Recognition of Abnormal Cells by Leukocyte Receptors
Anton van der Merwe
Investigating the mechanisms by which leukocytes use cell surface receptors to recognise infected or otherwise abnormal cells
Assembly and Regulation of Macromolecular Ciliary Dynein Motors
Girish Ram Mali
Investigating how cells assemble axonemal dyneins, in particular the role of DNAAFs in this process
The Transcriptional Cyclin-Dependent Kinases and Control of Gene Expression
Shona Murphy
Understanding the mechanisms underlying the connection between transcription and RNA processing
Cell Cycle and Gene Expression in Cancer
Chris Norbury
Studying the role of cyclin-dependent protein kinases (CDKs) in cancer cells and their normal counterparts
RNA Polymerase II Derived Nascent Transcription and Co-transcriptional RNA Processing in Mammalian Genomes
Nicholas Proudfoot
Studying the molecular mechanisms that define the extent of transcription units generated by RNA polymerase II across mammalian genomes
Centrioles, Centrosomes and Cilia in Health and Disease
Jordan Raff
Understanding how centrioles assemble and function, using a combination of biochemistry, genetics, live-cell imaging, computational/structural analysis and mathematical modelling
Motor Proteins, Cilia and Intracellular Organisation
Anthony Roberts
Investigating how motor proteins generate movement and spatial organisation within living cells and organelles.
Transcriptional Regulators of Mammalian Development
Elizabeth Robertson
Exploiting genetic strategies to identify the key signalling cues and downstream transcriptional regulators that mediate cell fate decisions in the developing mouse embryo
Mechanisms of Virus Biogenesis and Immune Evasion
Sumana Sanyal
Investigating mechanisms of flavivirus biogenesis, using Zika and Dengue as models, and their strategies of evading host immune responses
Lymphocyte function in health and disease
Quentin Sattentau
The Sattentau group has relocated to the Max Delbruck Centre for Molecular Medicine, Berlin-Buch.
Poxvirus Evasion of Innate Immunity
Geoffrey L Smith
Studying the mechanisms by which orthopoxviruses suppress innate immunity
Molecular Mucosal Immunology
Emma Slack
Elucidating the mechanisms by which the mucosal immune system can control the abundance and pathogenicity of opportunistic pathogens
Mechanisms and Prevention of Antibiotic Resistance and Tolerance
Mathew Stracy
Studying how bacteria respond to antibiotics from multiple perspectives; ranging from molecular biology to infection epidemiology
Bacterial Pathogenesis: Molecular Mechanisms to Prevention
Christoph Tang
Understanding how pathogens colonise specific niches in the body, evade elimination by the immune system, and cause disease
Bacterial pathogenesis and innate immune signaling
Teresa Thurston
Elucidating the mechanisms by which intracellular bacteria overcome the host’s innate immune response.
Structural Biology of Molecular Machines, from Atoms to Cellular Context
Katerina Toropova
Discovering how molecular machines perform essential cellular functions using cryo-electron microscopy/tomography and live fluorescence imaging.
Molecular Pathology of Post-Translational Modification
David Vaux
Studying the molecular mechanisms by which pathological perturbations in the post-translational modifications of proteins can lead to severe human disease