Herman Waldmann
Herman Waldmann is currently Emeritus Professor of Pathology at the University of Oxford. He was Head of the Sir William Dunn School of Pathology at Oxford from 1994-2012. As an immunologist, he is best known for his work on immunological tolerance and for pioneering monoclonal antibodies as therapeutics.
His mechanistic studies of immunological tolerance uncovered a role for regulatory T cells in ‘infectious’ tolerance, published in a seminal paper in Science in 1993. The strategies emerging from the Waldmann laboratory since that time have been based on the use of therapeutic antibodies to enhance regulation over conventional T cell immunity. In order to apply antibodies clinically, they developed the first academic antibody therapeutic manufacturing facility. This enabled them to apply clinical-grade antibodies in a wide range of probing therapeutic studies, leading them to trial a series of humanized antibodies (eg. targetting CD52, CD3, CD4 and others) which have since been transferred to the pharmaceutical industry.
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