MPS1 localizes to end-on microtubule-attached kinetochores to promote microtubule release.
Hayward, D., Roberts, E. and Gruneberg, U.
Curr Biol. – 32(23): 5200-5208.e8.
The association of Plk1 with the astrin-kinastrin complex promotes formation and maintenance of a metaphase plate.
Geraghty, Z., Barnard, C., Uluocak, P. and Gruneberg, U.
J Cell Sci. – 134(1): jcs251025.
PP1 promotes cyclin B destruction and the metaphase-anaphase transition by dephosphorylating CDC20.
Bancroft, J., Holder, J., Geraghty, Z., Alfonso-Perez, T., Murphy, D., Barr, F.A. and Gruneberg, U.
Mol Biol Cell – 31(21): 2315-2330.
Checkpoint signaling and error correction require regulation of the MPS1 T-loop by PP2A-B56.
Hayward, D., Bancroft, J., Mangat, D., Alfonso-Perez, T., Dugdale, S., McCarthy, J., Barr, F.A., and Gruneberg, U.
J Cell Biol. – 218(10): 3188-3199.
Orchestration of the spindle assembly checkpoint by CDK1-cyclin B1.
Hayward, D., Alfonso-Perez, T. and Gruneberg, U.
FEBS Lett. – 593(20):2889-2907.
CDK1-CCNB1 creates a spindle checkpoint-permissive state by enabling MPS1 kinetochore localization.
Hayward, D., Alfonso-Perez, T., Cundell, M.J., Hopkins, M., Holder, J., Bancroft, J., Hutter, L.H., Novak, B., Barr, F.A. and Gruneberg, U.
J Cell Biol. – 218(4): 1182-1199.
MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling.
Alfonso-Perez, T., Hayward, D., Holder, J., Gruneberg, U. and Barr, F.A.
J Cell Biol. – 218(4): 1108-1117.
PP2A-B56 opposes Mps1 phosphorylation of Knl1 and thereby promotes spindle assembly checkpoint silencing.
Espert, A., Uluocak, P., Bastos, R.N., Mangat, D., Graab, P. and Gruneberg, U.
J Cell Biol. – 206(7): 833-42.
A changing view of how MPS1 initiates the Spindle Assembly Checkpoint
A new study published in Current Biology by the Gruneberg lab advances our understanding of the mechanisms by which cells correct mistakes during chromosome segregation. 3.8 million duplicated genomes have to segregate equally into daughter cells every second in our body to maintain normal cell and tissue function. Any problem in the chromosome segregation process...
Prestigious BSCB prize for Iona Manley
The Gruneberg lab student was recognised with the BSCB Young Cell Biologist of the Year Prize At the recent BSCB/BSDB joint spring conference at the University of Warwick, Iona Manley, a 4th year PhD student in the Gruneberg lab, won this year’s BSCB Young Cell Biologist of the Year Prize with her poster “A novel...
Prof Ulrike Gruneberg awarded a Discovery Programme Award by CRUK
These prestigious 5-year grants from Cancer Research UK (CRUK) “provide long-term support for outstanding established scientists in basic or translational research fields” under CRUK’s overarching aim: “to bring forward the day when all cancers are cured”. Prof Gruneberg first established her research group at the University of Liverpool, joining the Dunn school in 2013, and...
Three Dunn School academics recognised with Full Professor title
Many congratulations to Omer Dushek, Fumiko Esashi and Ulrike Gruneberg We are delighted to announce that three Dunn School group leaders were recognised in this year’s University of Oxford Recognition of Distinction exercise. Omer Dushek is now Professor of Molecular Immunology. His group investigates the immunology of T cell receptor signal integration, at the interface...