Centromeres as universal hotspots of DNA breakage, driving RAD51-mediated recombination during quiescence.
Saayman, X., Graham, E., Nathan, W.J., Nussenzweig, A. and Esashi, F.
Molecular Cell – 83: 523-538.e7.
KAT2-mediated acetylation switches the mode of PALB2 chromatin association to safeguard genome integrity.
Fournier, M., Rodrigue, A., Milano, L., Bleuyard, J.Y., Couturier, A.M., Wall, J., Ellins, J., Hester, S., Smerdon, S.J., Tora, L., Masson, J.Y. and Esashi, F.
eLife – 11: e57736.
The RAD51 recombinase protects mitotic chromatin in human cells.
Wassing, I.E., Graham, E., Saayman, X., Rampazzo, L., Ralf, C., Bassett, A. and Esashi, F.
Nature Communications – 12(1): 5380.
Molecular flexibility of DNA as a key determinant of RAD51 recruitment.
Paoletti, F., El-Sagheer, A.H., Allard, J., Brown, T., Dushek, O. and Esashi, F.
EMBO J. – 39: e103002.
MRG15-mediated tethering of PALB2 to unperturbed chromatin protects active genes from genotoxic stress.
Bleuyard, J.Y., Fournier, M., Nakato, R., Couturier, A.M., Katou, Y., Ralf, C., Hester, S.S., Dominguez, D., Rhodes, D., Humphrey, T.C., Shirahige, K. and Esashi, F.
Proc Natl Acad Sci U S A. – 114: 7671-7676.
BRCA2 coordinates the activities of cell-cycle kinases to promote genome stability.
Yata, K., Bleuyard, J.Y., Nakato, R., Ralf, C., Katou, Y., Schwab, R.A., Niedzwiedz, W., Shirahige, K. and Esashi, F.
Cell Rep. – 7: 1547-1559.
Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.
Yata, K., Lloyd, J., Maslen, S., Bleuyard, J.Y., Skehel, M., Smerdon, S.J. and Esashi, F.
Molecular Cell – 45: 371-83.
ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair.
Bleuyard, J.Y., Buisson, R., Masson, J.Y. and Esashi, F.
EMBO Rep. – 13: 135-41.
New technique shows centromeres are hotspots for DNA breaks
Published in Molecular Cell, the Esashi lab demonstrates a new technique for detecting DNA breaks, which they use to show that centromeres are hotspots for DNA breaks.
Three Dunn School academics recognised with Full Professor title
Many congratulations to Omer Dushek, Fumiko Esashi and Ulrike Gruneberg We are delighted to announce that three Dunn School group leaders were recognised in this year’s University of Oxford Recognition of Distinction exercise. Omer Dushek is now Professor of Molecular Immunology. His group investigates the immunology of T cell receptor signal integration, at the interface...