Centriole growth is limited by the Cdk1/Cyclin-dependent phosphorylation of Ana2/STIL.
Steinacker, T.L., Wong, S-S., Novak, S.A., Saurya, S., Gartenmann, L., van Houtum, E.J.H., Sayers, J.R., Lagerholm, B.C. and Raff, J.W.
J Cell Biol. – 221(9): e202205058.
Centrioles generate a local pulse of Polo/PLK1 activity to initiate mitotic centrosome assembly.
Wong, S-S., Wilmott, Z.M., Saurya, S., Alvarez-Rodrigo, I., Zhou, F.Y., Chau, K-Y., Goriely, A. and Raff, J.W.
EMBO J. – 41(11): e110891.
An autonomous oscillation times and executes centriole biogenesis.
Aydogan, M.G., Steinacker, T.L., Mofatteh, M., Wilmott, Z., Zhou, F.Y., Gartenmann, L., Wainman, A., Saurya, S., Novak, Z.A., Wong, S.S., Goriely, A., Boemo, M.A. and Raff, J.W.
Cell – 181(7):1566-1581.e27.
Drosophila Sas-6, Ana2 and Sas-4 self-organise into macromolecular structures that can be used to probe centriole and centrosome assembly.
Gartenmann, L., Vicente, C.C., Wainman, A., Novak, Z.A., Sieber, B., Richens, J.H. and Raff, J.W.
J Cell Sci. – 133(12): jcs244574.
Evidence that a positive feedback loop drives centrosome maturation in fly embryos.
Alavarez Rodrigo, I., Steinacker, T.L., Saurya, S., Conduit, P.T., Baumbach, J., Novak, Z.A., Aydogan, M.G., Wainman, A. and Raff, J.W.
eLife – 8: e50130.
A homeostatic clock sets daughter centriole size in flies.
Aydogan, M.G., Wainman, A., Saurya, S., Steinacker, T.L., Caballe, A., Novak, Z.A., Baumbach, J., Muschalik, N. and Raff, J.W.
J Cell Biol. – 217(4): 1233-1248.
Structural basis for mitotic centrosome assembly in flies.
Feng, Z., Caballe, A., Wainman, A., Johnson, S., Haensele, A.F.M., Cottee, M.A., Conduit, P.T., Lea, S.M. and Raff, J.W.
Cell – 169(6): 1078-1089
Protein phosphorylation-mediated control of centriole growth
Published in the Journal of Cell Biology, work by the Raff lab uncovers a key new mechanism mediated by protein phosphorylation that regulates centriole growth and duplication during the cell cycle. The cell cycle is a highly regulated cellular process required for tissue development and homeostasis, whose dysregulation is associated with cancer. Centrioles are microtubule-based...
Pulse to the beat: centrosome assembly requires a pulse of Polo kinase activity
In a story published in the EMBO Journal, Wong, Wilmott et al. shed light on the mechanism of Polo action in the assembly of the centrosome. Cell division is an essential function of cells, and appropriate partitioning of DNA and other cellular materials is critical for the daughter cells’ functioning and survival. In animals, this process...
Susan Lea and Jordan Raff elected Fellows of the Royal Society
Many congratulations to Susan and Jordan for this prestigious honour, recognising their contributions to structural and centrosome biology, respectively.
Jordan Raff receives Excellence in Science Award
Awarded by the Biochemical Society, this honour recognises his leading role in the field of centriole and centrosome biology.