Minimizing treatment-induced emergence of antibiotic resistance in bacterial infections.
Stracy, M., Snitser, O., Yelin, I., Amer, Y., Parizade, M., Rimler, G., Wolf, T., Herzel, E., Koren, G., Kuint, J., Foxman, B., Chodick, G., Shalev, V. and Kishony, R.
Science – 375(6583): 889-894.
Transient non-specific DNA binding dominates the target search of bacterial DNA-binding proteins.
Stracy, M., Schweizer, J., Sherratt, D., Kapanidis, A.N., Uphoff, S. and Lesterlin, C.
Molecular Cell – 81(7): 1499-1514.e6.
Single-molecule imaging of UvrA and UvrB recruitment to DNA lesions in living Escherichia Coli.
Stracy, M., Jaciuk, M., Uphoff, S., Kapanidis, A.N., Nowotny, M., Sherratt, D.J. and Zawadzki, P.
Nucleic Acid Research – 47(1): 210-220.
Live-cell superresolution microscopy reveals the organization of RNA polymerase in the bacterial nucleoid.
Stracy, M., Lesterlin, C., Garza de Leon, F., Uphoff, S., Zawadzki, P. and Kapanidis, A.N.
Proc Natl Acad Sci U.S.A. – 112(32): E4390-9.
Dunn School strengthens its research on bacterial pathogenesis
Dr Georgia Isom and Dr Mathew Stracy lead two new research groups in the Dunn School. March marks the beginning of a new phase at the Dunn School with the arrival of two new research groups, led by Dr Georgia Isom and Dr Mathew Stracy. Both Dr Isom and Dr Stracy have secured highly competitive...
Antibiotic-prescribing algorithm reduces the risk of antibiotic resistance emergence in patients
New paper by the Stracy group uses machine learning to predict individual risk and develop personalised treatment strategies Antibiotics have saved countless lives but their widespread use has led to antibiotic resistance which is increasing throughout the world and threatens our ability to treat dangerous bacterial infections. Despite the significant health and economic burden, little...