Centrioles, Centrosomes and Cilia in Health and Disease
Jordan Raff
Understanding how centrioles assemble and function, using a combination of biochemistry, genetics, live-cell imaging, computational/structural analysis and mathematical modelling
Motor Proteins and Intracellular Organisation
Anthony Roberts
Investigating how motor proteins generate movement and spatial organisation within living cells
Transcriptional Regulators of Mammalian Development
Elizabeth Robertson
Exploiting genetic strategies to identify the key signalling cues and downstream transcriptional regulators that mediate cell fate decisions in the developing mouse embryo
Mechanisms of Virus Biogenesis and Immune Evasion
Sumana Sanyal
Investigating mechanisms of flavivirus biogenesis, using Zika and Dengue as models, and their strategies of evading host immune responses
Lymphocyte function in health and disease
Quentin Sattentau
Interrogating B cell responses to glycans and small molecules, and regulation of the T cell glycocalyx.
Molecular Mucosal Immunology
Emma Slack
Elucidating the mechanisms by which the mucosal immune system can control the abundance and pathogenicity of opportunistic pathogens
Poxvirus Evasion of Innate Immunity
Geoffrey L Smith
Studying the mechanisms by which orthopoxviruses suppress innate immunity
Mechanisms and Prevention of Antibiotic Resistance and Tolerance
Mathew Stracy
Studying how bacteria respond to antibiotics from multiple perspectives; ranging from molecular biology to infection epidemiology
Bacterial Pathogenesis: Molecular Mechanisms to Prevention
Christoph Tang
Understanding how pathogens colonise specific niches in the body, evade elimination by the immune system, and cause disease
Recognition of Abnormal Cells by Leukocyte Receptors
Anton van der Merwe
Investigating the mechanisms by which leukocytes use cell surface receptors to recognise infected or otherwise abnormal cells
Molecular Pathology of Post-Translational Modification
David Vaux
Studying the molecular mechanisms by which pathological perturbations in the post-translational modifications of proteins can lead to severe human disease