RNase H2, mutated in Aicardi-Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation.
Cristini, A., Tellier, M., Constantinescu, F., Accalai, C., Albulescu, L.O., Heiringhoff, R., Bery, N., Sordet, O., Murphy, S. and Gromak, N.
Nature Communications – 13(1): 2961.
N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells.
Abakir, A., Giles, T.C., Cristini, A., Foster, J.M., Dai, N., Starczak, M., Rubio-Roldan, A., Li, M., Eleftheriou, M., Crutchley, J., Flatt, L., Young, L., Gaffney, D.J., Denning, C., Dalhus, B., Emes, R.D., Gackowski, D., Corrêa Jr, I.R., Garcia-Perez, J.L., Klungland, A., Gromak, N.* and Ruzov, A.*
Nature Genetics – 52(1):48-55.
RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA Damage.
Cristini, A., Groh, M., Kristiansen, M.S. and Gromak, N.
Cell Reports – 23(6): 1891-1905.
Increased global transcription activity as a mechanism of replication stress in cancer.
Kotsantis, P., Marques Silva, L., Irmscher, S., Jones, R.M., Folkes, L., Gromak, N.* and Petermann, E.*
Nature Communications – 7: 13087.
Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination.
Skourti-Stathaki, K., Proudfoot, N.J.* and Gromak, N.*
Molecular Cell – 42(6): 794-805.
R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome.
Groh, M., Lufino, M., Wade-Martins, R. and Gromak, N.
PLoS Genetics – 10(5): e1004318.
How Breast Cancer Hijacks a Natural Enzyme to Boost Mutations
Natalia Gromak secures prestigious MRC Senior Research Fellowship
This highly competitive, 5 year fellowship will support the Gromak group’s investigation of R-loops in health and disease.
Novel insight into transcriptional functions of RNase H2 furthers our understanding of Aicardi Goutières Syndrome pathology
Published in Nature Communications, work by the Gromak lab uncovers key new functions for RNase H2 during transcription, and provides molecular explanations for the pathology behind Aicardi Goutières Syndrome. Aicardi Goutières Syndrome (AGS) is a severe neuroinflammatory disease caused by mutations in RNase H2 in more than 50% of the cases. RNase H2 is an...