Inefficient exploitation of accessory receptors reduces the sensitivity of chimeric antigen receptors.
Burton,J., Siller-Farfan, J.A., Pettmann, J., Salzer, B., Kutuzov, M., van der Merwe, P.A. and Dushek, O.
Proc Natl Acad Sci USA. – 20(2): e2216352120.
Mechanical forces impair antigen discrimination by reducing differences in T cell receptor off-rates.
Pettmann, J., Awada, L., Bartosz, R., Huhn, A., Faour, S., Kutuzov, M., Limozin, L., Weikl, T.R., van der Merwe, P.A., Robert, P. and Dushek, O.
EMBO J. – 42(7): e111841.
The discriminatory power of the T cell receptor.
*Pettmann, J., *Huhn, A., *Abu Shah, E., Kutuzov, M.A., Wilson, D.B., Dustin, M.L., Davis, S.J., van der Merwe, P.A. and Dushek, O.
eLife – 10: e67092.
Phenotypic models of T cell activation.
Lever, M., Maini, P.K., van der Merwe, P.A. and Dushek, O.
Nature Reviews Immunology – 14(9): 619-29.
Non-catalytic tyrosine-phosphorylated receptors.
Dushek, O., Goyette, J. and van der Merwe, P.A.
Immunological Reviews – 250(1): 258-76.
Improving the sensitivity of therapeutic receptors for cancer therapy
Published in PNAS, a new paper by the Dushek group shows how the effectiveness of therapeutic chimeric antigen receptors might be improved for cancer treatment
Three Dunn School academics recognised with Full Professor title
Many congratulations to Omer Dushek, Fumiko Esashi and Ulrike Gruneberg We are delighted to announce that three Dunn School group leaders were recognised in this year’s University of Oxford Recognition of Distinction exercise. Omer Dushek is now Professor of Molecular Immunology. His group investigates the immunology of T cell receptor signal integration, at the interface...