Research Groups

There are currently over 30 research groups at the Dunn School, with leaders drawn from across the world. Their diverse interests, backgrounds and expertise creates a dynamic and stimulating environment. Many groups share common research interests which fosters the vibrant scientific community found at the Dunn School.

Ervin Fodor

Ervin Fodor

Influenza virus replication at the molecular level

Influenza viruses are important human and animal pathogens. They cause widespread clinical and veterinary disease and have a considerable economic impact. Our laboratory focuses on the fundamental molecular mechanisms of influenza virus replication, aiming to understand the molecular determinants of host range and...

Matthew Freeman

Matthew Freeman

Cell biology of intercellular signalling

The main questions we study are what cellular mechanisms regulate signalling between animal cells, and how does that signalling control biological functions like physiology, development and pathology?

David Greaves

David Greaves

Regulation of inflammatory responses in vivo

Inflammation is the response of vascularised tissues to injury, metabolic disturbance and infection. Acute inflammation typically lasts only a few days while chronic inflammation can last for months or years, and is a defining feature of many important human diseases including rheumatoid arthritis and coronary heart disease...

Natalia Gromak

Natalia Gromak

R-loop biology in health and disease

Our research focuses on understanding the mechanisms governing gene regulation in humans in health and disease conditions. In particular, we are interested in unusual RNA/DNA structures, called R-loops. These are three-stranded structures formed during transcription and composed of an RNA hybridising to a complementary DNA strand,...

Ulrike Gruneberg

Ulrike Gruneberg

Regulation of mitotic progression and chromosome segregation

Cell division is the fundamental basis for growth and development of an organism. Millions of cell divisions have to occur before an organism reaches its final size. Throughout the life span of an organism, blood, skin and intestinal cells have to be constantly replaced by further cell division. High fidelity...

Monika Gullerova

Monika Gullerova

RNA dependent DNA damage response

Genetic information stored in DNA is continuously exposed to endogenous or exogenous damaging factors. Efficient DNA damage repair is a fundamental process for every living organism. The accumulation of DNA damage affects cellular viability and leads to a variety of diseases, particularly cancer. 

Bass Hassan

Bass Hassan

Structure and function of genes that regulate tumour phenotypes

Multiple cellular pathways are deregulated in tumours as a result of gene disruption, some of which alter growth and the propensity for tumour cells to invade and spread to other body sites.  The importance of an experimental understanding of the basic science that underpins our knowledge of tumour...

William James

William James

Macrophage modulation during viral infection and neuroinflammation

We are in the James & Lillian Martin Centre, Sir William Dunn School of Pathology, University of Oxtord

The macrophage is a key cell in human health and disease, and we have...

Susan Lea

Susan Lea

The Lea group has now relocated to the Center for Structural Biology at the NIH National Cancer Institute, USA, maintaining a small team at the Dunn School.

Host-pathogen interactions

An understanding of the way in which an invading pathogen interacts with its host at a molecular level is an essential aid to understanding the nature and extent of...

Anton van der Merwe

Anton van der Merwe

Recognition of abnormal cells by leukocyte receptors

My group studies the mechanisms by which leukocytes, such as T cells, use cell surface receptors to recognise infected or otherwise abnormal cells. The T cell receptor (TCR) plays a major role in this process by probing the surfaces of cells for the presence of 'foreign' peptides presented on MHC molecules in a...

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