Research groups

There are currently over 30 research groups at the Dunn School, investigating different aspects of the molecular and cellular basis underlying health and disease.
Research area:

DNA Repair Mechanisms and Human Disease

Ivan Ahel

Exploring the pathways underlying genome stability, in particular the role of the post-translational protein modification ADP-ribosylation

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Caspase Functions Beyond Apoptosis

Luis Alberto Baena

Deciphering emerging functions of caspases

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Organelle Biogenesis and Homeostasis

Pedro Carvalho

Investigating the role of the ER in protein degradation and organelle biogenesis.

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Genome Stability and Evolution

Fumiko Esashi

Investigating the mechanisms that drive changes in the genome during cell growth and dormancy

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Cell Biology of Signalling

Matthew Freeman

Investigating the interface between membrane proteins, the cell biology of signalling, and mechanisms of human disease

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Regulation of Mitotic Progression and Chromosome Segregation

Ulrike Gruneberg

Elucidating how faithful chromosome segregation during cell division is ensured, and how this goes awry in cancer

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Macrophage Modulation During Viral Infection and Neuroinflammation

William James

Dissecting both physiological and pathological macrophage pathways in infectious and non-infectious disease

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Recognition of Abnormal Cells by Leukocyte Receptors

Anton van der Merwe

Investigating the mechanisms by which leukocytes use cell surface receptors to recognise infected or otherwise abnormal cells

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Assembly and Regulation of Macromolecular Ciliary Dynein Motors

Girish Ram Mali

Investigating how cells assemble axonemal dyneins, in particular the role of DNAAFs in this process

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Centrioles, Centrosomes and Cilia in Health and Disease

Jordan Raff

Understanding how centrioles assemble and function, using a combination of biochemistry, genetics, live-cell imaging, computational/structural analysis and mathematical modelling

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Motor Proteins and Intracellular Organisation

Anthony Roberts

Investigating how motor proteins generate movement and spatial organisation within living cells

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Transcriptional Regulators of Mammalian Development

Elizabeth Robertson

Exploiting genetic strategies to identify the key signalling cues and downstream transcriptional regulators that mediate cell fate decisions in the developing mouse embryo

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Mechanisms of Virus Biogenesis and Immune Evasion 

Sumana Sanyal

Investigating mechanisms of flavivirus biogenesis, using Zika and Dengue as models, and their strategies of evading host immune responses

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Poxvirus Evasion of Innate Immunity

Geoffrey L Smith

Studying the mechanisms by which orthopoxviruses suppress innate immunity

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Molecular Pathology of Post-Translational Modification

David Vaux

Studying the molecular mechanisms by which pathological perturbations in the post-translational modifications of proteins can lead to severe human disease

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