Centrioles, Centrosomes and Cilia in Health and Disease
Jordan Raff
Understanding how centrioles assemble and function, using a combination of biochemistry, genetics, live-cell imaging, computational/structural analysis and mathematical modelling
Motor Proteins and Intracellular Organisation
Anthony Roberts
Investigating how motor proteins generate movement and spatial organisation within living cells
Transcriptional Regulators of Mammalian Development
Elizabeth Robertson
Exploiting genetic strategies to identify the key signalling cues and downstream transcriptional regulators that mediate cell fate decisions in the developing mouse embryo
Mechanisms of Virus Biogenesis and Immune Evasion
Sumana Sanyal
Investigating mechanisms of flavivirus biogenesis, using Zika and Dengue as models, and their strategies of evading host immune responses
Poxvirus Evasion of Innate Immunity
Geoffrey L Smith
Studying the mechanisms by which orthopoxviruses suppress innate immunity
Recognition of Abnormal Cells by Leukocyte Receptors
Anton van der Merwe
Investigating the mechanisms by which leukocytes use cell surface receptors to recognise infected or otherwise abnormal cells
Molecular Pathology of Post-Translational Modification
David Vaux
Studying the molecular mechanisms by which pathological perturbations in the post-translational modifications of proteins can lead to severe human disease