Centrioles, Centrosomes and Cilia in Health and Disease
Jordan Raff
Understanding how centrioles assemble and function, using a combination of biochemistry, genetics, live-cell imaging, computational/structural analysis and mathematical modelling
Motor Proteins, Cilia and Intracellular Organisation
Anthony Roberts
Investigating how motor proteins generate movement and spatial organisation within living cells and organelles.
Transcriptional Regulators of Mammalian Development
Elizabeth Robertson
Exploiting genetic strategies to identify the key signalling cues and downstream transcriptional regulators that mediate cell fate decisions in the developing mouse embryo
Mechanisms of Virus Biogenesis and Immune Evasion
Sumana Sanyal
Investigating mechanisms of flavivirus biogenesis, using Zika and Dengue as models, and their strategies of evading host immune responses
Poxvirus Evasion of Innate Immunity
Geoffrey L Smith
Studying the mechanisms by which orthopoxviruses suppress innate immunity
Bacterial pathogenesis and innate immune signaling
Teresa Thurston
Elucidating the mechanisms by which intracellular bacteria overcome the host’s innate immune response.
Structural Biology of Molecular Machines, from Atoms to Cellular Context
Katerina Toropova
Discovering how molecular machines perform essential cellular functions using cryo-electron microscopy/tomography and live fluorescence imaging.
Recognition of Abnormal Cells by Leukocyte Receptors
Anton van der Merwe
Investigating the mechanisms by which leukocytes use cell surface receptors to recognise infected or otherwise abnormal cells
Molecular Pathology of Post-Translational Modification
David Vaux
Studying the molecular mechanisms by which pathological perturbations in the post-translational modifications of proteins can lead to severe human disease