We study processes that are critical for maintaining genome integrity and normal cell growth. These include DNA replication and repair, and the role of post-transcriptional regulation of gene expression. Our work seeks to understand how defects in the cell's machinery can ultimately lead to the development of cancer and other diseases. The insights we gain will help to identify novel therapeutic and diagnostic strategies.
We investigate the mechanisms that are central to a range of important cellular processes such as signaling, transcriptional control, cell division, protein trafficking, and genome maintenance. Our research is largely aimed at understanding these processes in human cells, but we are also interested in how they are adapted in other eukaryotes, including medically important parasites.
Our work exploits the ability to manipulate embryonic stem cells for fundamental and translational research. We focus on understanding the molecular pathways underlying cellular interactions during mammalian development and immune recognition. We also explore how to overcome the immunological barriers to using stem cells for regenerative medicine.
Our researchers use a range of approaches to investigate antigen presentation and immune regulation during health and disease. We study the mechanisms that enable bacterial, parasitic, and viral pathogens to invade and proliferate inside their hosts. Insights gained through these studies are being exploited to manipulate immune responses and develop vaccines.
Our research focuses on the diverse ways RNA levels and gene expression are controlled by cells. We use a range of molecular biology approaches to investigate fundamental aspects mechanisms of transcription, transcriptional gene silencing, and RNA processing. By shedding light on these pathways, we aim to define their role in diseases as diverse as neurodegeneration and malignancy.