DNA Repair Mechanisms and Human Disease
Ivan Ahel
Exploring the pathways underlying genome stability, in particular the role of the post-translational protein modification ADP-ribosylation
Caspase Functions Beyond Apoptosis
Luis Alberto Baena
Deciphering emerging functions of caspases
Organelle Biogenesis and Homeostasis
Pedro Carvalho
Investigating the role of the ER in protein degradation and organelle biogenesis.
Genome Stability and Evolution
Fumiko Esashi
Investigating the mechanisms that drive changes in the genome during cell growth and dormancy
Cell Biology of Signalling
Matthew Freeman
Investigating the interface between membrane proteins, the cell biology of signalling, and mechanisms of human disease
Regulation of Mitotic Progression and Chromosome Segregation
Ulrike Gruneberg
Elucidating how faithful chromosome segregation during cell division is ensured, and how this goes awry in cancer
Macrophage Modulation During Viral Infection and Neuroinflammation
William James
Dissecting both physiological and pathological macrophage pathways in infectious and non-infectious disease
Assembly and Regulation of Macromolecular Ciliary Dynein Motors
Girish Ram Mali
Investigating how cells assemble axonemal dyneins, in particular the role of DNAAFs in this process
Recognition of Abnormal Cells by Leukocyte Receptors
Anton van der Merwe
Investigating the mechanisms by which leukocytes use cell surface receptors to recognise infected or otherwise abnormal cells
Centrioles, Centrosomes and Cilia in Health and Disease
Jordan Raff
Understanding how centrioles assemble and function, using a combination of biochemistry, genetics, live-cell imaging, computational/structural analysis and mathematical modelling
Motor Proteins and Intracellular Organisation
Anthony Roberts
Investigating how motor proteins generate movement and spatial organisation within living cells
Transcriptional Regulators of Mammalian Development
Elizabeth Robertson
Exploiting genetic strategies to identify the key signalling cues and downstream transcriptional regulators that mediate cell fate decisions in the developing mouse embryo
Mechanisms of Virus Biogenesis and Immune Evasion
Sumana Sanyal
Investigating mechanisms of flavivirus biogenesis, using Zika and Dengue as models, and their strategies of evading host immune responses
Poxvirus Evasion of Innate Immunity
Geoffrey L Smith
Studying the mechanisms by which orthopoxviruses suppress innate immunity
Molecular Pathology of Post-Translational Modification
David Vaux
Studying the molecular mechanisms by which pathological perturbations in the post-translational modifications of proteins can lead to severe human disease