Molecular Mechanisms of RNA Virus Replication
Ervin Fodor
Elucidating the fundamental mechanisms underlying the replication of RNA viruses such as Influenza, Nipah, and SARS-CoV-2
R-Loop Biology in Health and Disease
Natalia Gromak
Studying the role of a unique type of non-canonical RNA/DNA structure in healthy cells and in neurodegenerative diseases.
RNA Dependent DNA Damage Response and Gene Expression Regulation
Monika Gullerova
Understanding how intronic gene silencing is de-regulated in cancer cells and how synthetic tsRNA can be used therapeutically
Structure and Function of Cancer Genes
Bass Hassan
Identifying and validating functional genomic co-dependencies to improve precision of cancer treatment.
The Transcriptional Cyclin-Dependent Kinases and Control of Gene Expression
Shona Murphy
Understanding the mechanisms underlying the connection between transcription and RNA processing
Cell Cycle and Gene Expression in Cancer
Chris Norbury
Studying the role of cyclin-dependent protein kinases (CDKs) in cancer cells and their normal counterparts
RNA Polymerase II Derived Nascent Transcription and Co-transcriptional RNA Processing in Mammalian Genomes
Nicholas Proudfoot
Studying the molecular mechanisms that define the extent of transcription units generated by RNA polymerase II across mammalian genomes
Bacterial Pathogenesis: Molecular Mechanisms to Prevention
Christoph Tang
Understanding how pathogens colonise specific niches in the body, evade elimination by the immune system, and cause disease
Molecular Pathology of Post-Translational Modification
David Vaux
Studying the molecular mechanisms by which pathological perturbations in the post-translational modifications of proteins can lead to severe human disease