Mechanisms of Genome Stability
Dragana Ahel
Uncovering the mechanisms that maintain genome integrity
DNA Repair Mechanisms and Human Disease
Ivan Ahel
Exploring the pathways underlying genome stability, in particular the role of the post-translational protein modification ADP-ribosylation
Genome Stability and Evolution
Fumiko Esashi
Investigating the mechanisms that drive changes in the genome during cell growth and dormancy
Germline mutation and Meiotic recombination
Anjali Hinch
Uncovering the mechanisms and impacts of meiotic recombination and de novo mutation.
Regulation of Mitotic Progression and Chromosome Segregation
Ulrike Gruneberg
Elucidating how faithful chromosome segregation during cell division is ensured, and how this goes awry in cancer
RNA Dependent DNA Damage Response and Gene Expression Regulation
Monika Gullerova
Understanding how intronic gene silencing is de-regulated in cancer cells and how synthetic tsRNA can be used therapeutically
Structure and Function of Cancer Genes
Bass Hassan
Identifying and validating functional genomic co-dependencies to improve precision of cancer treatment.
Cell Cycle and Gene Expression in Cancer
Chris Norbury
Studying the role of cyclin-dependent protein kinases (CDKs) in cancer cells and their normal counterparts
Centrioles, Centrosomes and Cilia in Health and Disease
Jordan Raff
Understanding how centrioles assemble and function, using a combination of biochemistry, genetics, live-cell imaging, computational/structural analysis and mathematical modelling
Molecular Pathology of Post-Translational Modification
David Vaux
Studying the molecular mechanisms by which pathological perturbations in the post-translational modifications of proteins can lead to severe human disease