TRIM5α restricts poxviruses and is antagonized by CypA and the viral protein C6.
Zhao, Y., Lu, Y., Richardson, S., Sreekumar, M., Albarnaz, J.D. & Smith, G.L
Nature – 620(7975):873-880.
Smallpox vaccination induces a substantial increase in commensal skin bacteria that promote pathology and influence the host response.
Shmeleva, E.V., Gomez de Agüero, M., Wagner, J., Enright, A.J., Macpherson, A.J., Ferguson, B.J., & Smith, G.L.
PLoS Pathogens – 18, e1009854.
Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling.
Talbot-Cooper, C., Pantelejevs, T., Shannon, J.P., Cherry, C.R., Au, M.T., Hyvönen, M., Hickman, H.D. and Smith, G.L.
Cell Host Microbe – 30(3): 357-372.e11.
Molecular mimicry of NF-κB by vaccinia virus protein enables selective inhibition of antiviral responses.
Albarnaz, J.D., Ren, H., Torres, A.A., Shmeleva, E.V., de Melo, C.M.A.G., Bannister, A.J. and Smith, G.L.
Nature Microbiology – 7(1): 154-168.
Histone deacetylase 4 promotes type I interferon signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6.
Lu, Y., Stuart, J.H., Talbot-Cooper, C., Agrawal-Singh, SA., Huntly, B., Smid, A.I., Snowden, J.S., Dupont, L.. and Smith, G.L.
Proc. Natl. Acad. Sci. USA – 116(24): 11997-12006.
Study of Poxviruses Leads to New Treatment Avenues
Published in Nature, a new study led by Prof Geoffrey L. Smith sheds light on how poxviruses evade host defences, and suggests a new way of treating these infections with existing drugs.
Prof Geoffrey L Smith (re)joins the Dunn School
We are delighted to welcome an expert on poxviruses to the department!