The ability of cilia to concentrate a unique set of membrane proteins underlies processes as diverse as vision, olfaction, appetite control, and developmental signalling. Evidence suggests that membrane protein transport into cilia relies on massive molecular “trains” that move along the ciliary microtubules under the power of kinesin and dynein motors.
This project involves using cryo-EM, cryo-ET, FIB milling, and biochemical approaches to understand the basis for membrane protein transport into cilia, building on recent advances in the group (Cell 2022, PMID: 36462505). The research will be conducted in a friendly and supportive atmosphere with access to outstanding facilities and within a vibrant postdoc community.
The post-holder should hold, or be close to completion of, a PhD/DPhil in Structural Biology, Biochemistry, or Cell Biology. Expertise in protein purification and structure determination are essential for this position. Experience in cryo-EM, cryo-ET, or FIB milling would be an advantage, but is not essential as training can be provided.
The post-holder will be responsible for managing their own academic research, establishing and optimising protocols, designing and accurately executing experiments, and contributing conceptually to the overall research programme. Good organisational and communication skills and the ability to work as part of a team are essential.
This is a full-time position available for 3 years in the first instance, with a possibility of extension. If you are interested in this role, and have the skills and experience we are looking for, please apply online. You will be required to upload a CV and supporting statement as part of your online application. The supporting statement should describe how you fit the criteria for the role, including your motivation and curiosity about the research project.
Informal enquiries about this post can be addressed to Dr Anthony Roberts: anthony.roberts@path.ox.ac.uk
The closing date for applications is 12.00 midday on 25 September 2023. Interviews will be held in October.