Omer Dushek

Molecular immunology of signal integration by T cell surface receptors

T cells are important white blood cells that continually circulate in the body in search of the molecular signatures ('antigens') of infection and cancer. When encountering such antigens T cells become activated and subsequently initiate immune responses in order to clear these threats. Their inappropriate activation towards innocuous and endogenous antigens leads to allergic and autoimmune responses, respectively. A key aim of the laboratory is to understand the 'calculation' that T cells make in deciding to respond to abnormal cells whilst ignoring healthy cells.

T cells (red) interacting with antigen presenting cells (green)

Schematic of signalling proximal to the T cell antigen receptor

The calculation that T cells make is performed by their complex signalling machinery that integrates signals from the T cell receptor with a host of other, accessory, receptors on their surface. We are using a combination of quantitative experiments and mathematical modelling to uncover the biochemical mechanisms used by T cells to integrate these signals.

Relevant Publications

Siller‐Farfán, JA, Dushek, O
2018

Immunological Reviews 285:194-205

Goyette, J, Solis Salas, C, Coker-Gordon, N, Bridge, M, Isaacson, SA, Allard, J, Dushek, O.
2017

Science Advances 3: e1601692.

Lever M, Lim HS, Kruger P, Nguyen J, Trendel N, Abu-Shah, Maini PK, van der Merwe PA, Dushek O.
2016

Proc Natl Acad Sci USA.

Dushek O, van der Merwe PA
2014

Trends in Immunology 35: 153-8.

Lever M, Maini PK, van der Merwe PA, Dushek O
2014

Nature Reviews Immunology 14: 619-29.

omer.dushek@path.ox.ac.uk

Research Areas