Morphogenesis and pathogenicity of trypanosome and Leishmania parasites.
Our research focuses on African trypanosomes, particularly the structural and molecular mechanisms of cell proliferation and differentiation, in relation to pathogenesis. We have particular interests in the following: the molecular cytology of the flagellum and its roles in the host-parasite and parasite-vector interaction; the molecules that link the microtubule cytoskeleton to surface membrane and the reasons for membrane protein restriction to particular domains; and, how these components operate to orchestrate cell shape and facilitate shape modulations during the cell cycle and the parasite life cycles.
We also conduct studies on the Leishmania parasites and have a firm interest in comparative studies, so providing an evolutionary cell biology context for much of our research.
Our studies include a variety of approaches and expertise, ranging from advanced light and electron microscopy to proteomics, biochemistry, cell and molecular biological studies of mutants, through to comparative genomics.
Cell 156: 1247-1258.
Journal of Cell Biology 206: 377–384.
Journal of Cell Science 126: 5748-5757.
Proc Natl Acad Sci U S A 106: 17425-17430.