Ervin Fodor

Influenza virus replication at the molecular level

Influenza viruses are important human and animal pathogens. They cause widespread clinical and veterinary disease and have a considerable economic impact. Our laboratory focuses on the fundamental molecular mechanisms of influenza virus replication, aiming to understand the molecular determinants of host range and virulence of influenza viruses. By gaining further insights into the molecular details of influenza virus replication we hope to facilitate the development of novel strategies to combat influenza.

RNA polymerase of influenza C virus (image courtesy of Kamel El Omari)

A cRNP, the helical, rod-shaped replicative intermediate of the influenza genome.

Influenza A viruses contain a genome consisting of eight single stranded negative-sense RNA segments assembled into ribonucleoprotein complexes with an RNA-dependent RNA polymerase and multiple copies of nucleoprotein. We address questions ranging from how the influenza virus RNA polymerase transcribes and replicates the viral RNA genome in the nucleus of the infected cell to how the RNA genome is exported from the nucleus and assembles into infectious progeny virus particles. We are also interested in the role of host factors in viral replication as well as in understanding the effects of virus infection on the host cell, the molecular mechanisms of innate immune sensing and host cell responses to viral infection.

We collaborate with structural biologists, physicists, chemists and immunologists, using an interdisciplinary approach, including molecular and cell biology, structural biology (x-ray crystallography and cryo-electron microscopy), single molecule and super-resolution microscopy, proteomics and virology.


Relevant Publications

te Velthuis AJW, Grimes JM, Fodor E

Nature Reviews Microbiology 19: 303-318.

Carrique L, Fan H, Walker AP, Keown JR, Sharps J, Staller E, Barclay WS, Fodor E, Grimes JM

Nature 587: 638-643.

Fan H, Walker AP, Carrique L, Keown JR, Serna Martin I, Karia D, Sharps J, Hengrung N, Pardon E, Steyaert J, Grimes JM, Fodor E

Nature 573: 287-290.

Dadonaite B, Gilbertson B, Knight ML, Trifkovic S, Rockman S, Laederach A, Brown LE, Fodor E, Bauer DLV

Nature Microbiology 4: 1781-1789.

te Velthuis AJW, Long JC, Bauer DLV, Fan RLY, Yen HL, Sharps J, Siegers JY, Killip MJ, French H, Oliva-Martín MJ, Randall RE, de Wit E, van Riel D, Poon LLM, Fodor E

Nature Microbiology 3: 1234-1242.

Hengrung N, El Omari K, Serna Martin I, Vreede FT, Cusack S, Rambo RP, Vonrhein C, Bricogne G, Stuart DI, Grimes JM, Fodor E

Nature 527: 114-117.