David Greaves

Regulation of inflammatory responses in vivo

Inflammation is the response of vascularised tissues to injury, metabolic disturbance and infection. Acute inflammation typically lasts only a few days while chronic inflammation can last for months or years, and is a defining feature of many important human diseases including rheumatoid arthritis and coronary heart disease.

Macrophages with actin stained green and DNA in blue.

Inflamed human fallopian tube with neutrophils (dark blue nuclei) in a blood vessel.

The Greaves Laboratory is studying the role played by a family of inflammatory mediators called chemokines in the recruitment and activation of monocytes and macrophages during chronic inflammation. We are interested in the role chemokines play in atherosclerosis - a disease process that occurs in arteries causing angina, heart attacks, strokes and peripheral arterial disease.

We want to use our basic science understanding of inflammation biology to develop novel classes of anti-inflammatory drugs. We are using two different approaches, drug re-purposing (e.g. Purvis et al.) and chemical biology (e.g. Lucy et al.)

Current work in the laboratory seeks too identify molecules that can regulate the efficiency of macrophage phagocytosis of both microrganisms such as bacteria and apoptotic neutrophils a process called efferocytosis.

 

Relevant Publications

Purvis GSD , Collino M, Aranda-Tavio H, Chiazza F, O'Riordan CE, Zeboudj L, Mohammad S, Collotta D, Verta R, Guisot NES, Bunyard P, Yaqoob MM, Greaves DR, Thiemermann C
2020

Br J Pharmacol. doi: 10.1111/bph.15182. 

Lucy D, Purvis GSD, Zeboudj L, Chatzopoulou M, Recio C, Bataille CJR, Wynne GM, Greaves DR , Russell AJ
2019

ACS Chem Biol 14(9):2055-2064. doi: 10.1021/acschembio.9b00533

Recio C, Lucy D, Purvis GSD, Iveson P, Zeboudj L, Iqbal AJ, Lin D, O'Callaghan C, Davison L, Griesbach E, Russell AJ, Wynne GM, Dib L, Monaco C, Greaves DR.
2018

Front Immunol. 9:1419. doi: 10.3389/fimmu.2018.01419.

Regan-Komito D, Valaris S, Kapellos TS, Recio C, Taylor L, Greaves DR, Iqbal AJ.
2017

Front Immunol. 8:1621. doi: 10.3389/fimmu.2017.01621.

Iqbal AJ, Fisher EA, Greaves DR.
2016

Microbiol Spectr. 4(5). doi: 10.1128/microbiolspec.MCHD-0027-

david.greaves@path.ox.ac.uk

Research Areas