RNA and Gene expression

RNA and Gene expression

The following groups perform research in this area:

Peter Cook

Transcription factories; genome organization and gene regulation.

Human chromosomes are arguably the largest and most important biomolecules, but many aspects of their structure – and how structure affects function – remain unresolved. Our ultimate goal is to elucidate how the genome is folded, and how folding determines function. To this end, we apply a multi-...

Ervin Fodor

Influenza virus replication at the molecular level

Influenza viruses are important human and animal pathogens. They cause widespread clinical and veterinary disease and have a considerable economic impact. Our laboratory seeks to understand fundamental aspects of the structure and function of influenza viruses, as well as virus:host interactions including host responses...

Natalia Gromak

Molecular mechanisms of neurodegenerative diseases

Our research focuses on understanding the mechanisms governing gene regulation in humans in health and disease conditions. We are investigating the molecular basis of neurodegenerative diseases arising from dysregulation of RNA transcription and processing. We study Friedreich ataxia (FRDA) and Fragile X syndrome (FXS...

Monika Gullerova

Transcriptional gene silencing and its role in disease.

Our goal is to understand the role of transcriptional gene silencing in gene expression regulation in mammalian cells. Our research focuses on natural occurrence of sense and antisense overlapping transcripts that lead to RNAi activation in normal and cancer cells. To elucidate these research questions, we employ...

Bass Hassan

Structure and function of genes that regulate tumour phenotypes

Multiple cellular pathways are deregulated in tumours, some of which alter growth and the propensity for tumour cells to invade and spread to other sites. Our group focuses on two imprinted genes frequently disrupted in cancer, IGF2 ligand and IGF2 receptor (IGF2R). We have studied the structural basis of...

Shona Murphy

The CTD of RNA polymerase II and elongation checkpoints

During transcription of both protein-coding and snRNA genes by RNA polymerase II (pol II), transcription and RNA processing are tightly coupled. Our most recent work has focused on understanding the mechanics of this connection.

 

Chris Norbury

Post-transcriptional regulation of gene expression in cancer.

We study post-transcriptional aspects of gene regulation, and specifically how these differ between cancer cells and their normal counterparts. One project in this area focuses on translation initiation factor eIF3e (also known as INT6), high levels of which in breast cancer are...

Nicholas Proudfoot

Gene punctuation: Transcriptional termination in eukaryotes.

We study molecular mechanisms that define the extent of transcription units in mammalian genomes by focusing on the molecular mechanism of RNA polymerase II (Pol II) termination.

Christoph Tang

Bacterial pathogenesis: molecular mechanisms to prevention

Human bacterial pathogens are a specialized subset of array microbes we encounter as part of our flora. The group seeks to understand the basis of how pathogens colonise specific niches in the body, evade elimination by the immune system, and cause disease. We study Neisseria spp., which are leading...

David Vaux

Molecular pathology of post-translational modification

The group is interested in the molecular mechanisms by which pathological perturbations in the post-translational modifications of proteins (including proteolytic maturation, oligomeric assembly, ubiquitination, phosphorylation and fatty acyl modification) can lead to severe human disease. Conditions resulting from...