There are currently over 30 research groups at the Dunn School, with leaders drawn from across the world. Their diverse interests, backgrounds and expertise creates a dynamic and stimulating environment. Many groups share common research interests which fosters the vibrant scientific community found at the Dunn School.
Molecular dissection of centrioles, centrosomes and cilia
Centrioles organise the assembly of two important cell organelles: centrosomes and the cilia; our goal is to understand how these organelles function at the molecular level.
Transcriptional regulators of mammalian development
Our research exploits mouse genetics to investigate the key signalling cues and transcriptional regulators governing cell fate decisions in the developing mammalian embryo. In particular, we have been studying the TGF family of secreted growth factors, including the ligand Nodal, and its downstream effector Smad2,...
SUMANA SANYAL WILL JOIN THE DUNN SCHOOL IN JANUARY 2020
Flavivirus biogenesis and their strategies for host immune evasion
Dengue and Zika represent two of the major mosquito-borne flaviviruses that collectively have huge health implications worldwide. Dengue infects approximately 400 million people annually, often causing severe pathologies...
Advancing understanding of HIV pathogenesis and vaccine design
Our current research spans the fields of HIV-1 dissemination, HIV-1 antibody-based vaccine design, and the molecular basis of allergy. We use a multi-disciplinary approach, which includes immunology, virology, chemistry, and cell biology together with cutting-edge imaging techniques to address fundamental...
Bacterial pathogenesis: molecular mechanisms to prevention
Human bacterial pathogens are a specialized subset of array microbes we encounter as part of our flora. The group seeks to understand the basis of how pathogens colonise specific niches in the body, evade elimination by the immune system, and cause disease. We study Neisseria spp., which are leading...
Molecular pathology of post-translational modification
The group is interested in the molecular mechanisms by which pathological perturbations in the post-translational modifications of proteins (including proteolytic maturation, oligomeric assembly, ubiquitination, phosphorylation and fatty acyl modification) can lead to severe human disease. Conditions resulting from...
DNA replication and genome stability
Complete, accurate replication of the genome is crucial for life. Errors during DNA replication give rise to mutations that cause genetic disease; failures during genome replication directly underlie several human disorders. DNA replication is the direct target of many chemotherapeutic agents.