Infection and Immunity

Infection and Immunity

The following groups perform research in this area:

Susan Lea

Susan Lea

The Lea group has now relocated to the Center for Structural Biology at the NIH National Cancer Institute, USA, maintaining a small team at the Dunn School.

Host-pathogen interactions

An understanding of the way in which an invading pathogen interacts with its host at a molecular level is an essential aid to understanding the nature and extent of...

Anton van der Merwe

Anton van der Merwe

Recognition of abnormal cells by leukocyte receptors

My group studies the mechanisms by which leukocytes, such as T cells, use cell surface receptors to recognise infected or otherwise abnormal cells. The T cell receptor (TCR) plays a major role in this process by probing the surfaces of cells for the presence of 'foreign' peptides presented on MHC molecules in a...

Sumana Sanyal

Sumana Sanyal

Flavivirus biogenesis and their strategies for host immune evasion

Dengue and Zika represent two of the major mosquito-borne flaviviruses that collectively have huge health implications worldwide. Dengue infects approximately 400 million people annually, often causing severe pathologies such as vascular endothelial leakage. Zika too has emerged as a global threat with...

Quentin Sattentau

Quentin Sattentau

Advancing understanding of HIV pathogenesis and vaccine design

Our current research spans the fields of HIV-1 dissemination, HIV-1 antibody-based vaccine design, and the molecular basis of allergy. We use a multi-disciplinary approach, which includes immunology, virology, chemistry, and cell biology together with cutting-edge imaging techniques to address fundamental...

Christoph Tang

Christoph Tang

Bacterial pathogenesis: molecular mechanisms to prevention

Human bacterial pathogens are a specialized subset of the array microbes we encounter as part of our flora. The group seeks to understand the basis of how pathogens colonise specific niches in the body, evade elimination by the immune system, and cause disease. We study Neisseria spp., which are leading...

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