Infection and Immunity

Infection and Immunity

The following groups perform research in this area:

Oreste Acuto

Oreste Acuto

Oreste Acuto has now retired, but can still be contacted on the email address on this page

Molecular mechanisms of T cell activation and differentiation

We are interested in understanding how T cells, central actors of adaptive immune responses, become activated when they encounter foreign substances. Dissecting the molecular underpinning of this process...

Ivan Ahel

Ivan Ahel

DNA repair mechanisms and human disease

Our genome is constantly exposed to various types of DNA damage, both endogenous and exogenous. It has been estimated that the DNA in every cell of our body suffers thousands of DNA lesions per day, which, if left unattended, can lead to mutations and/or cell death. Our cells have evolved a variety of mechanisms to counteract...

Tanmay Bharat

From April 2022, Tanmay Bharat's group will be located at the MRC laboratory of Molecular Biology in Cambridge, maintaining a small team at the Dunn School.

Structural cell biology of bacterial biofilm formation

Rather than living as single, isolated cells in liquid cultures, most bacteria on this planet form macroscopic, surface-attached,...

Marion H Brown

Marion H Brown

Marion Brown has now retired, but can still be contacted on the email address on this page.

Molecular interactions of leukoctye surface receptors

We study how immune regulation depends on molecular interactions of leukocyte surface receptors. The overall effect of a receptor can vary from activation to inhibition. It is critical to understand how this is...

Omer Dushek

Omer Dushek

Molecular immunology of signal integration by T cell surface receptors

T cells are important white blood cells that continually circulate in the body in search of the molecular signatures ('antigens') of infection and cancer. When encountering such antigens T cells become activated and subsequently initiate immune responses in order to clear these threats. Their...

Paul Fairchild

Paul Fairchild

Paul Fairchild has now left the Dunn School. He can be contacted via the spin out company OXvax and the email address on this page.

Exploring the interface between immunology and regenerative medicine

Although the dramatic increase in life expectancy over the past century is arguably one of medicine’s greatest successes, it is also responsible for the...

Ervin Fodor

Ervin Fodor

Influenza virus replication at the molecular level

Influenza viruses are important human and animal pathogens. They cause widespread clinical and veterinary disease and have a considerable economic impact. Our laboratory focuses on the fundamental molecular mechanisms of influenza virus replication, aiming to understand the molecular determinants of host range and...

Matthew Freeman

Matthew Freeman

Cell biology of intercellular signalling

The main questions we study are what cellular mechanisms regulate signalling between animal cells, and how does that signalling control biological functions like physiology, development and pathology?

David Greaves

David Greaves

Regulation of inflammatory responses in vivo

Inflammation is the response of vascularised tissues to injury, metabolic disturbance and infection. Acute inflammation typically lasts only a few days while chronic inflammation can last for months or years, and is a defining feature of many important human diseases including rheumatoid arthritis and coronary heart disease...

Georgia Isom

Georgia Isom

Molecular mechanisms of bacterial membrane biogenesis

Using structural biology, biochemistry, and microbiology to study the molecular mechanisms by which Gram-negative bacteria build their outer membranes and protect themselves against antibiotics.

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