Research Groups

There are currently over 30 research groups at the Dunn School, with leaders drawn from across the world. Their diverse interests, backgrounds and expertise creates a dynamic and stimulating environment. Many groups share common research interests which fosters the vibrant scientific community found at the Dunn School.

Bass Hassan

Structure and function of genes that regulate tumour phenotypes

Multiple cellular pathways are deregulated in tumours, some of which alter growth and the propensity for tumour cells to invade and spread to other sites. Our group focuses on two imprinted genes frequently disrupted in cancer, IGF2 ligand and IGF2 receptor (IGF2R). We have studied the structural basis of...

William James

Macrophage modulation during viral infection and neuroinflammation

Tissue macrophages, including the microglia in the brain, act as critical sentinels to defend us against infection. Consequently, pathogens such as HIV have developed ways of circumventing the defensive functions of macrophages in order to establish chronic infection. Moreover, their persistence in...

Susan Lea

The Lea group has now relocated to the Center for Structural Biology at the NIH National Cancer Institute, USA, maintaining a small team at the Dunn School.

Host-pathogen interactions

An understanding of the way in which an invading pathogen interacts with its host at a molecular level is an essential aid to understanding the nature and extent of...

Anton van der Merwe

Recognition of abnormal cells by leukocyte receptors

My group studies the mechanisms by which leukocytes, such as T cells, use cell surface receptors to recognise infected or otherwise abnormal cells. The T cell receptor (TCR) plays a major role in this process by probing the surfaces of cells for the presence of 'foreign' peptides presented on MHC molecules in a...

Shona Murphy

The CTD of RNA polymerase II and elongation checkpoints

During transcription of both protein-coding and snRNA genes by RNA polymerase II (pol II), transcription and RNA processing are tightly coupled. Our most recent work has focused on understanding the mechanics of this connection.


Chris Norbury

Post-transcriptional regulation of gene expression in cancer.

We study post-transcriptional aspects of gene regulation, and specifically how these differ between cancer cells and their normal counterparts. One project in this area focuses on translation initiation factor eIF3e (also known as INT6), high levels of which in breast cancer are...

Nicholas Proudfoot

Gene punctuation: Transcriptional termination in eukaryotes.

We study the molecular mechanisms that define the extent of transcription units generated by RNA polymerase II (Pol II) across mammalian genomes. Especially how do protein coding transcripts differ from long noncoding transcripts in their mode of synthesis and coupled RNA processing?