There are currently over 30 research groups at the Dunn School, with leaders drawn from across the world. Their diverse interests, backgrounds and expertise creates a dynamic and stimulating environment. Many groups share common research interests which fosters the vibrant scientific community found at the Dunn School.
Genome Stability and Cell Cycle
Our research goal is to elucidate how proliferating human cells safeguard their genomic DNA against various stresses coming from the environment (e.g., UV, radiation, chemicals) and from normal processes of cell growth (e.g., metabolic byproducts, DNA replication, transcription).
Exploring the interface between immunology and regenerative medicine
Although the dramatic increase in life expectancy over the past century is arguably one of medicine’s greatest successes, it is also responsible for the rising incidence of chronic and degenerative diseases throughout the developed world. The properties of induced pluripotent stem cells (iPSC) offer an...
Influenza virus replication at the molecular level
Influenza viruses are important human and animal pathogens. They cause widespread clinical and veterinary disease and have a considerable economic impact. Our laboratory focuses on the fundamental molecular mechanisms of influenza virus replication, aiming to understand the molecular determinants of host range and...
Cell biology of intercellular signalling
The main questions we study are what cellular mechanisms regulate signalling between animal cells, and how does that signalling control biological functions like physiology, development and pathology?
Molecular cell biology of Leishmania
We study single-celled parasites called Leishmania, which cause disease in humans and animals in over 88 countries around the world. Leishmaniasis is a neglected disease, associated with poverty and conflict. There is currently no vaccine and an urgent need for better drug treatments.
Regulation of inflammatory responses in vivo
Inflammation is the response of vascularised tissues to injury, metabolic disturbance and infection. Acute inflammation typically lasts only a few days while chronic inflammation can last for months or years, and is a defining feature of many important human diseases including rheumatoid arthritis and coronary heart disease...
Molecular mechanisms of neurodegenerative diseases
Our research focuses on understanding the mechanisms governing gene regulation in humans in health and disease conditions. We are investigating the molecular basis of neurodegenerative diseases arising from dysregulation of RNA transcription and processing. We study Friedreich ataxia (FRDA) and Fragile X syndrome (FXS...
Regulation of mitotic progression and chromosome segregation
Cell division is the fundamental basis for growth and development of an organism. Millions of cell divisions have to occur before an organism reaches its final size. Throughout the life span of an organism, blood, skin and intestinal cells have to be constantly replaced by further cell division. High fidelity...
RNA dependent DNA damage response
Genetic information stored in DNA is continuously exposed to endogenous or exogenous damaging factors. Efficient DNA damage repair is a fundamental process for every living organism. The accumulation of DNA damage affects cellular viability and leads to a variety of diseases, particularly cancer.