Cell Biology

Cell Biology

The following groups perform research in this area:

Oreste Acuto

Oreste Acuto

Oreste Acuto has now retired, but can still be contacted on the email address on this page

Molecular mechanisms of T cell activation and differentiation

We are interested in understanding how T cells, central actors of adaptive immune responses, become activated when they encounter foreign substances. Dissecting the molecular underpinning of this process...

Ivan Ahel

Ivan Ahel

DNA repair mechanisms and human disease

Our genome is constantly exposed to various types of DNA damage, both endogenous and exogenous. It has been estimated that the DNA in every cell of our body suffers thousands of DNA lesions per day, which, if left unattended, can lead to mutations and/or cell death. Our cells have evolved a variety of mechanisms to counteract...

Luis Alberto Baena

Luis Alberto Baena

Deciphering the emerging functions of caspases

Most of the scientific focus on the evolutionarily conserved family of caspases has been aimed at understanding their role as key regulators of cell death. However, recent evidence suggests the involvement of these proteins in alternative cellular functions such as cell proliferation, cell differentiation and cell migration...

Tanmay Bharat

From April 2022, Tanmay Bharat's group will be located at the MRC laboratory of Molecular Biology in Cambridge, maintaining a small team at the Dunn School.

Structural cell biology of bacterial biofilm formation

Rather than living as single, isolated cells in liquid cultures, most bacteria on this planet form macroscopic, surface-attached,...

Pedro Carvalho

Pedro Carvalho

Organelle biogenesis and homeostasis

A defining feature of eukaryotic cells is the presence of a variety of membrane-bound organelles. Each one of these organelles has a specialized set of functions and a unique identity conferred by a distinct set of lipid and protein molecules. Our lab studies how organelle identity, function and architecture is generated and...

Fumiko Esashi

Fumiko Esashi

Genome Stability and Cell Cycle

Our research goal is to elucidate how proliferating human cells safeguard their genomic DNA against various stresses coming from the environment (e.g., radiation, genotoxic agents) and from normal processes of cell growth (e.g., DNA replication, transcription & mitotic chromosome dynamics).

Matthew Freeman

Matthew Freeman

Cell biology of intercellular signalling

The main questions we study are what cellular mechanisms regulate signalling between animal cells, and how does that signalling control biological functions like physiology, development and pathology?

Ulrike Gruneberg

Ulrike Gruneberg

Regulation of mitotic progression and chromosome segregation

Cell division is the fundamental basis for growth and development of an organism. Millions of cell divisions have to occur before an organism reaches its final size. Throughout the life span of an organism, blood, skin and intestinal cells have to be constantly replaced by further cell division. High fidelity...

Jordan Raff

Jordan Raff

Molecular dissection of centrioles, centrosomes and cilia

Centrioles organise the assembly of two important cell organelles: centrosomes and the cilia; our goal is to understand how these organelles function at the molecular level.

Anthony Roberts

Anthony Roberts

The Roberts lab will be joining the Dunn School in April 2023.

Motor Proteins and Intracellular Organisation

We are investigating the mechanisms by which motor proteins generate movement and spatial organisation within living cells. We are also interested in how defects in these mechanisms cause human pathologies. To address these topics, our work...

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