Cell Biology

Cell Biology

The following groups perform research in this area:

Oreste Acuto

Molecular mechanisms of T cell activation and differentiation

We are interested in understanding how T cells, central actors of adaptive immune responses, become activated when they encounter foreign substances. Dissecting the molecular underpinning of this process may lead to the discovery new and more effective ways to diagnose, prevent and heal immune dysfunction...

Ivan Ahel

DNA repair mechanisms and human disease

Our genome is constantly exposed to various types of DNA damage, both endogenous and exogenous. It has been estimated that the DNA in every cell of our body suffers thousands of DNA lesions per day, which, if left unattended, can lead to mutations and/or cell death. Our cells have evolved a variety of mechanisms to counteract...

Luis Alberto Baena

Deciphering the emerging functions of caspases

Most of the scientific focus on the evolutionarily conserved family of caspases has been aimed at understanding their role as key regulators of cell death. However, recent evidence suggests the involvement of these proteins in alternative cellular functions such as cell proliferation, cell differentiation and cell migration...

Tanmay Bharat

Structural cell biology of bacterial biofilm formation

The majority of bacteria on earth do not exist as single isolated cells but rather form macroscopic, surface-attached, multi-cellular communities known as biofilms. Bacterial biofilms play a role in many diseases and infectious processes like cystic fibrosis and urinary tract infections. Biofilms may also form on...

Pedro Carvalho

Organelle biogenesis and homeostasis

A defining feature of eukaryotic cells is the presence of a variety of membrane-bound organelles. Each one of these organelles has a specialized set of functions and a unique identity conferred by a distinct set of lipid and protein molecules. Our lab studies how organelle identity, function and architecture is generated and...

Peter Cook

Transcription factories; genome organization and gene regulation.

Human chromosomes are arguably the largest and most important biomolecules, but many aspects of their structure – and how structure affects function – remain unresolved. Our ultimate goal is to elucidate how the genome is folded, and how folding determines function. To this end, we apply a multi-...

Fumiko Esashi

Genome Stability and Cell Cycle

Our research goal is to elucidate how proliferating human cells safeguard their genomic DNA against various stresses coming from the environment (e.g., UV, radiation, chemicals) and from normal processes of cell growth (e.g., metabolic byproducts, DNA replication, transcription).

Matthew Freeman

Cell biology of intercellular signalling

The main questions we study are what cellular mechanisms regulate signalling between animal cells, and how does that signalling control biological functions like physiology, development and pathology?

Eva Gluenz

Molecular cell biology of Leishmania

Leishmania are protozoan parasites, transmitted by sand flies, which cause a spectrum of disease, ranging from potentially disfiguring cutaneous lesions to life threatening systemic infections. Leishmania parasites have two principal life cycle stages: promastigote forms in the sand fly and amastigote forms...

Ulrike Gruneberg

Regulation of mitotic progression and chromosome segregation

Cell division is the fundamental basis for growth and development of an organism. Millions of cell divisions have to occur before an organism reaches its final size. Throughout the life span of an organism, blood, skin and intestinal cells have to be constantly replaced by further cell division. High fidelity...