Cancer and Genome stability

Cancer and Genome stability

The following groups perform research in this area:

Dragana Ahel

Mechanisms of genome stability

The maintenance of a complete and undamaged genome is critical for survival. Because DNA is continuously exposed to genotoxic stress, cells have evolved mechanisms that are specialized for correcting different types of DNA damage. These mechanisms play essential roles in the maintenance of genome integrity and their deficiencies have been...

Ivan Ahel

DNA repair mechanisms and human disease

Our genome is constantly exposed to various types of DNA damage, both endogenous and exogenous. It has been estimated that the DNA in every cell of our body suffers thousands of DNA lesions per day, which, if left unattended, can lead to mutations and/or cell death. Our cells have evolved a variety of mechanisms to counteract...

Peter Cook

Transcription factories; genome organization and gene regulation.

Human chromosomes are arguably the largest and most important biomolecules, but many aspects of their structure – and how structure affects function – remain unresolved. Our ultimate goal is to elucidate how the genome is folded, and how folding determines function. To this end, we apply a multi-...

Fumiko Esashi

Genome Stability and Cell Cycle

Our research goal is to elucidate how proliferating human cells safeguard their genomic DNA against various stresses coming from the environment (e.g., UV, radiation, chemicals) and from normal processes of cell growth (e.g., metabolic byproducts, DNA replication, transcription).

Ulrike Gruneberg

Regulation of mitotic progression and chromosome segregation

Cell division is the fundamental basis for growth and development of an organism. Millions of cell divisions have to occur before an organism reaches its final size. Throughout the life span of an organism, blood, skin and intestinal cells have to be constantly replaced by further cell division. High fidelity...

Bass Hassan

Structure and function of genes that regulate tumour phenotypes

Multiple cellular pathways are deregulated in tumours, some of which alter growth and the propensity for tumour cells to invade and spread to other sites. Our group focuses on two imprinted genes frequently disrupted in cancer, IGF2 ligand and IGF2 receptor (IGF2R). We have studied the structural basis of...

Conrad Nieduszynski

DNA replication and genome stability

Complete, accurate replication of the genome is crucial for life. Errors during DNA replication give rise to mutations that cause genetic disease; failures during genome replication directly underlie several human disorders. DNA replication is the direct target of many chemotherapeutic agents.

Chris Norbury

Post-transcriptional regulation of gene expression in cancer.

We study post-transcriptional aspects of gene regulation, and specifically how these differ between cancer cells and their normal counterparts. One project in this area focuses on translation initiation factor eIF3e (also known as INT6), high levels of which in breast cancer are...

Jordan Raff

Molecular dissection of centrioles, centrosomes and cilia

Centrioles organise the assembly of two important cell organelles: centrosomes and the cilia; our goal is to understand how these organelles function at the molecular level.

David Vaux

Molecular pathology of post-translational modification

The group is interested in the molecular mechanisms by which pathological perturbations in the post-translational modifications of proteins (including proteolytic maturation, oligomeric assembly, ubiquitination, phosphorylation and fatty acyl modification) can lead to severe human disease. Conditions resulting from...

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