Neil Barclay
EPA Professor of Chemical Pathology
Molecular Immunology Group
Structural and functional analysis of lymphocyte membrane proteins
| Web | Personal Website |
|---|---|
| neil.barclay@path.ox.ac.uk | |
| Contact address | Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE |
| Department | Sir William Dunn School of Pathology |
Prof Neil Barclay
The immune system is highly regulated through interactions of proteins at the surface of leukocytes. Our research focuses on the identification of these interactions, their biochemical characterisation and analysis of the signals that are transmitted on engagement. Some of these proteins are potential targets for therapeutics to regulate immune responses in immunity and cancer.
Research Details
- Characterisation of the molecular and functional outcomes following engagement of leukocyte membrane proteins by cell surface ligands (with Dr. M. H. Brown). Current foci include SIRP, CD200R, CD6, CD5, CD224 and their ligands.
- Structural determination of lymphocyte membrane proteins by X-ray crystallography including the paired receptor SIRP family, together with implications for function and evolution.
- Role of labile disulphides in membrane proteins in the regulation of immunity.
