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• Research
  • Structural and functional analysis of the influenza virus RNA polymerase
  • Molecular interactions between the viral transcriptional machinery and the host cell
  • The influenza virus RNA polymerase in the induction and inhibition of host innate immune pathways
  • Studentship project
  • Phosphorylation
  • Post-translational modifications of influenza virus proteins
• Publications
  • NS reassortment of an H7-type HPAIV affects its propagation by altering the regulation of viral RNA production and anti-viral host response.
  • Association of the influenza virus RNA polymerase subunit PB2 with the host chaperonin CCT.
  • The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon.
  • Splicing of influenza A virus NS1 mRNA is independent of the viral NS1 protein.
  • Functional analysis of the influenza virus H5N1 nucleoprotein tail loop reveals amino acids that are crucial for oligomerization and ribonucleoprotein activities.
  • RIG-I detects viral genomic RNA during negative-strand RNA virus infection.
  • Mechanisms and functional implications of the degradation of host RNA polymerase II in influenza virus infected cells.
  • NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome.
  • Nuclear dynamics of influenza A virus ribonucleoproteins revealed by live-cell imaging studies.
  • Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site.
  • Hsp90 inhibitors reduce influenza virus replication in cell culture.
  • A cluster of conserved basic amino acids near the C-terminus of the PB1 subunit of the influenza virus RNA polymerase is involved in the regulation of viral transcription.
  • Role of ran binding protein 5 in nuclear import and assembly of the influenza virus RNA polymerase complex.
  • Functional association between viral and cellular transcription during influenza virus infection.
  • Influenza virus inhibits RNA polymerase II elongation.
  • Characterization of a mitochondrial-targeting signal in the PB2 protein of influenza viruses.
  • In vitro assembly of PB2 with a PB1-PA dimer supports a new model of assembly of influenza A virus polymerase subunits into a functional trimeric complex.
  • Association of the influenza A virus RNA-dependent RNA polymerase with cellular RNA polymerase II.
  • The PA subunit is required for efficient nuclear accumulation of the PB1 subunit of the influenza A virus RNA polymerase complex.
  • Orthomyxovirus replication, transcription, and polyadenylation.
  • A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase promotes the generation of defective interfering RNAs.
  • Two aromatic residues in the PB2 subunit of influenza A RNA polymerase are crucial for cap binding.
  • Alternative base pairs attenuate influenza A virus when introduced into the duplex region of the conserved viral RNA promoter of either the NS or the PA gene.
  • Evaluation of a genetically modified reassortant H5N1 influenza A virus vaccine candidate generated by plasmid-based reverse genetics.
  • A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs.
  • The predicted antigenicity of the haemagglutinin of the 1918 Spanish influenza pandemic suggests an avian origin.
  • Messenger RNAs that are not synthesized by RNA polymerase II can be 3' end cleaved and polyadenylated.
  • Transcription and replication of the influenza a virus genome.
  • Reduced levels of neuraminidase of influenza A viruses correlate with attenuated phenotypes in mice.
  • Polyuridylated mRNA synthesized by a recombinant influenza virus is defective in nuclear export.
  • Rescue of influenza A virus from recombinant DNA.
  • Direct evidence that the poly(A) tail of influenza A virus mRNA is synthesized by reiterative copying of a U track in the virion RNA template.
  • Attenuation of influenza A virus mRNA levels by promoter mutations.
  • Polyadenylation of influenza virus mRNA transcribed in vitro from model virion RNA templates: requirement for 5' conserved sequences.
  • Mutational analysis of the RNA-fork model of the influenza A virus vRNA promoter in vivo.
  • In vitro transcription and polymerase binding studies of the termini of influenza A virus cRNA: evidence for a cRNA panhandle.
  • Solid phase synthesis of 5'-diphosphorylated oligoribonucleotides and their conversion to capped m7Gppp-oligoribonucleotides for use as primers for influenza A virus RNA polymerase in vitro.
  • Characterization of the RNA-fork model of virion RNA in the initiation of transcription in influenza A virus.
  • The influenza virus panhandle is involved in the initiation of transcription.
  • Photochemical cross-linking of influenza A polymerase to its virion RNA promoter defines a polymerase binding site at residues 9 to 12 of the promoter.
  • The role of the influenza virus RNA polymerase in host shut-off
  • Influenza virus replication
  • Differential use of importin-alpha isoforms governs cell tropism and host adaptation of influenza virus.
  • The Influenza A Virus NS1 Protein Interacts with the Nucleoprotein of Viral Ribonucleoprotein Complexes.
  • Influenza Polymerase Activity Correlates with the Strength of Interaction between Nucleoprotein and PB2 through the Host-Specific Residue K/E627.
  • The accumulation of influenza A virus segment 7 spliced mRNAs is regulated by the NS1 protein.
  • Stabilization of influenza virus replication intermediates is dependent on the RNA-binding but not the homo-oligomerization activity of the viral nucleoprotein.
  • Characterization of the interaction between the influenza A virus polymerase subunit PB1 and the host nuclear import factor Ran-binding protein 5.
  • Cellular cap-binding proteins associate with influenza virus mRNAs.
  • Emerging Roles for the Influenza A Virus Nuclear Export Protein (NEP).
  • Mapping the phosphoproteome of influenza a and B viruses by mass spectrometry.
  • Identification of a novel splice variant form of the influenza a virus m2 ion channel with an antigenically distinct ectodomain.
  • Pseudotyped influenza a virus as a vaccine for the induction of heterotypic immunity.
  • Nuclear import of the influenza A virus transcriptional machinery.
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