Perhaps the best-known achievement of this Department was attained during World War II, with the establishment of purification protocols for, and therapeutic usage of penicillin. For this work, Profs. H. W. Florey and E. B. Chain were awarded the Nobel Prize in Medicine in 1945, along with Prof. A. Fleming from St. Mary’s Hospital in London, who discovered the compound shortly after World War I. Subsequently, Prof. E. P. Abraham and Dr. G. F. Newton identified and patented cephalosporin antibiotics, which are structurally related to penicillins. Together these two families of compounds represent over 60% of all antibiotics clinically administered today. Presently, the Department has gathered together microbiologists studying viruses, archaea, bacteria and protozoan parasites at every level, whether genomic, molecular or cellular.
- Eva Gluenz
- Cell biology of Leishmania; role of the flagellum in host-parasite interactions
- Keith Gull
- Aspects of the pathogenicity of African trypanosomes and inherited ciliary diseases of humans.
- William James
- HIV-Macrophage interactions and stem cell technology
- Susan Lea
- Host-pathogen interactions including the Complement system, bacterial adhesion, type III and tat secretion systems and picornaviral-receptor interactions.
- Quentin Sattentau
- Retroviral Immunology.
- Christoph Tang
- Pathogenesis and Prevention of Bacterial Meningitis