|Contact address||Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE|
|Department||Sir William Dunn School of Pathology|
Our research exploits mouse genetics to investigate cell interactions underlying mammalian development and immune recognition. ES cell technology allows us to generate conditional mutations, knock-in alleles, perform cell marking experiments, and manipulate expression levels of key signalling molecules under physiological conditions in vivo.
TGFb signalling pathways in patterning the early body axis and in organogenesis
Transcriptional control of mesoderm induction and endoderm specification
Cell fate decisions governed by the zinc finger transcriptional repressor Blimp-1
Requirements for the molecular chaperones Ii chain and DM in guiding MHC class II antigen presentation