The Department has an extremely strong tradition of excellence in this field, going back to the discovery of lymphocyte recirculation by Prof. James Gowans and of the immunoglobulin superfamily by Prof. Alan Williams. More recently it has developed excellence in both innate and acquired immunity; the cellular basis of immunological tolerance and immunity; the signalling networks that underlie these processes ; the interplay between the immune system and microbes . More recently, the department has pioneered the application of therapeutic antibodies in transplantation, the treatment of immunological disorders and of cancer.
The biochemical basis of signal initiation and propogation, its fine tuning and stabilization that imparts during phenotypic changes.
Structural and functional analysis of lymphocyte membrane proteins
Molecular interactions in regulation by lymphocyte surface proteins
Systems Biology of Lymphocyte Signaling
Cell population array imaging
Host-pathogen interactions in the intestine and their impact on intestinal inflammation
Innate and adaptive immune pathways that control intestinal homeostasis and their breakdown in inflammatory bowel disease.
Molecular analysis of T and NK cell recognition.
Mechanisms of immune tolerance and how these can be harnessed, using to develop clinical treatments for human diseases that involve disregulation or inappropriate reactions of the Immune System.