David Vaux

My research interests are centred on the relationship between human disease and proteins altered by post-translational modifications, proteolytic processing or aberrant folding.  A wide variety of experimental techniques are used, extending from protein chemistry, mass spectrometry, planar bilayer electrophysiology and microarray analysis through to a range of digital imaging techniques at the light and electron microscope level.  Specific topics of current interest include:

Research Details

• Laminopathies and dynamic structural defects in the nuclear envelope
• The role of the nuclear envelope in regulated gene expression
• Extranuclear roles of BRCA1 in mitochondrial DNA repair and cell motility
• Acetylcholinesterase in the pathogenesis of Alzheimer's disease
• Peptide-phospholipid bilayer interaction and pathological channel formation as mechanisms of cytotoxicity
• MAPS (multimer analysis of phage sequences) for characterisation of complex surfaces

Click here for details of Graduate Student Project starting in October 2012