David Greaves
Reader in Molecular Pathology
Greaves Lab
Inflammation Biology.
| Web | Personal Website |
|---|---|
| david.greaves@path.ox.ac.uk | |
| Contact address | Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE |
| Department | Sir William Dunn School of Pathology |
Many human diseases including rheumatoid arthritis, allergic asthma, inflammatory bowel disease and angina are the result of chronic inflammation. Inflammation is a localised, response to injury or infection characterised by the recruitment of circulating white blood cells or leukocytes. Recruited leukocytes become activated at the site of inflammation and release a wide range of pro- and anti- inflammatory mediators.
My laboratory is studying the role played by a family of inflammatory mediators called chemokines in the recruitment and activation of macrophages and smooth muscle cells in chronic inflammation. We are particularly interested in the role chemokines play in atherosclerosis - a disease process in arteries that leads to angina, heart attacks, strokes and peripheral arterial disease.
Recent work in my laboratory has identified an endogenous anti-inflammatory pathway that involves the plasma protein chemerin and its receptor ChemR23 that can regulate inflammatory cell recruitment and activation and enhance macrophage phagocytosis of microbial debris and apoptotic cells. These studies may identify new targets for the development of anti-inflammatory drugs.
Research Details
- In vivo gene transfer using adenovirus and lentivirus vectors
- Measuring chemokine and cytokine production
- Models of peritoneal inflammation
- Macrophage activation assays
- Cell signalling assays
- Phagocytosis assays
- Chemotaxis assays
- FACS & ECIS
- qRT-PCR
