Peter Cook
EPA Professor of Cell Biology
Nuclear Structure and Function Research Group
To generate structural and functional maps of nuclei using a multi-disciplinary approach (e.g., combining molecular analysis, high-resolution imaging, and computer modelling).
| Web | Personal Website |
|---|---|
| peter.cook@path.ox.ac.uk | |
| Contact address | Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE |
| Department | Sir William Dunn School of Pathology |
Prof Peter Cook
We now know the exact sequence of most of the billions of bases in the human genome, but we still know almost nothing about how those bases are folded in 3-D space or how folding facilitates function. Our ultimate goal is to map these foldings and determine how the structure influences function. We apply a multi-disciplinary approach, combining molecular analyses, high-resolution imaging, and mathematical modelling.
Research Details
- Nuclear architecture and its relationship to function
- The higher-order structure of chromosomes
- Analysis of sites of replication, DNA repair, transcription, and protein synthesis in cell nuclei
- Modelling chromosome structure and function
