The SPR facility provides access to 3 SPR biosensor instruments and the core reagents and consumables required for experiments.

 

The Biacore 3000 for routine screening of protein-protein interactions

-Quantitative kinetic analysis (rate constants)

-Quantitative determination of affinity constants

-Concentration determination

-Determination of binding specificity (yes/no)

-Thermodynamic measurements

 

 

The Biacore T200 for ultra-low immobilisation experiments

-Obtain high quality kinetics from the fastest on-rates to the slowest off-rate

-Analyze interactions involving the smallest low molecular weight (LMW) compounds

-Automated and robust system - process up to 384 samples in unattended runs

-Flexible software with high-level user guidance - for fast assay development, analysis and evaluation

-Guided workflows with built-in data quality assessments and tools - get to final results faster

-Automated calibration free concentration analysis

 

 

 

 

 

 

The Bio-Rad XPR 36 for high throughput screening

-can analyze up to 36 different protein interactions in a single run, on a single chip

-can perform a complete kinetic analysis in a single run

-measures a variety of experimental conditions simultaneously in parallel

-It also can screen multiple panels of analytes

 

 

The team also provides training and advice on all aspects of your work including sample preparation, instrument operation, experiment design, and data analysis and interpretation.